The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit
نویسندگان
چکیده
منابع مشابه
The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit
Reversible ubiquitylation of proteins contributes to their integrity, abundance and activity. The RE1-silencing transcription factor (REST) plays key physiological roles and is dysregulated in a spectrum of disease. It is rapidly turned over and is phosphorylated, polyubiquitylated and degraded en masse during neuronal differentiation and cell cycle progression. Through siRNA screening we ident...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.25035